Study reveals dual effects of new osteoporosis therapy on bone tissue

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 26 2019Sclerostin is a protein produced by osteocytes in the bone that inhibits bone formation. A recent analysis of results from a clinical trial reveals the beneficial effects of romosozumab, an antibody therapy that targets sclerostin, on bone tissue in postmenopausal women with osteoporosis. The findings are published in the Journal of Bone and Mineral Research.Romosozumab increases serum markers of bone formation and decreases those of bone breakdown, or resorption. This is associated with an increased bone mineral density and a reduced risk of bone fractures.Related StoriesEarly exposure to antacids could put infants at risk for bone fractures during childhoodResearchers examine strains between bone and graft from animal modelsJefferson researcher discovers a population of bone cells that subdues cancerThis latest analysis included 107 patients with osteoporosis who were enrolled in the multicenter, phase 3 clinical trial called the Fracture Study in Postmenopausal Women with Osteoporosis (FRAME) study and who underwent bone biopsies. The analysis showed that at the tissue level, romosozumab produced an early and transient increase in bone formation and a persistent decrease in bone resorption. This led to significant increases in bone mass and improved bone microarchitecture (Figure) after 12 months of therapy. These effects contribute to the reduced fracture risk previously reported in postmenopausal women with osteoporosis treated with romosozumab. Source:WileyJournal reference:Chavassieux, P. et al. (2019) Bone‐Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment. Journal of Bone and Mineral Research. doi.org/10.1002/jbmr.3735. Romosozumab is the first osteoporosis therapy with a dual effect on bone tissue, increasing bone formation and decreasing resorption.”Lead author Dr. Pascale Chavassieux, of the University of Lyon, in Francelast_img read more

Monsanto CEO and others to leave after Bayer takeover

Citation: Monsanto CEO and others to leave after Bayer takeover (2018, May 7) retrieved 18 July 2019 from https://phys.org/news/2018-05-monsanto-ceo-bayer-takeover.html Monsanto Chairman and CEO Hugh Grant will leave the company after it’s acquired by Germany’s Bayer AG. The St. Louis company said Monday that Grant will work to see the $57 billion deal through and oversee operations before it closes. Bayer expects the deal to close in the second quarter.A number of Monsanto’s top executives will depart with Grant as well.Monsanto shareholders approved a bid from the pharmaceutical and chemical business in December.Monsanto sells seeds and crop protection chemicals to the agricultural sector. Monsanto shares jump on report of US approval of Bayer deal This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further © 2018 The Associated Press. All rights reserved. read more

New app offers interactive experiences for Disney guests

first_img Citation: New app offers interactive experiences for Disney guests (2018, June 29) retrieved 18 July 2019 from https://phys.org/news/2018-06-app-interactive-disney-guests.html Explore further With the opening of Toy Story Land at Hollywood Studies, Walt Disney World is also offering guests a new mobile app called Play Disney Parks. The app debuts Saturday, the same day that Toy Story Land opens to the public.Entertainment options include interactive themed games, Disney trivia, digital achievements and music playlists.Scott Andress is vice president of Digital Guest Experience for Disney. He explains that the app is designed to give people an alternative to a “heads down” cellphone experience. The idea is to turn wait times for rides into engaging entertainment for families and friends. It is available for iOS and Android platforms. It is free to download and use.The app can be used at the four parks just outside Orlando and two at Disneyland Resort. Want to see Disneyland without going there? Try Street View © 2018 The Associated Press. All rights reserved. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

UK fracking firm produces first shale gas

first_img Citation: UK fracking firm produces first shale gas (2018, November 2) retrieved 17 July 2019 from https://phys.org/news/2018-11-uk-fracking-firm-shale-gas.html Cuadrilla’s Preston New Road drilling site near the village of Little Plumpton in northwestern England last month © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. UK fracking firm Cuadrilla pauses drilling after tremorcenter_img Explore further UK energy company Cuadrilla said Friday it has extracted a small but “encouraging” amount of shale gas for the first time since resuming fracking in Britain less than three weeks ago. The 11-year-old private firm has borne the brunt of protests for trying to test whether fracking—a process in which water and chemicals are used to blast apart rock formations—can unlock natural gas deposits in the UK.The method has transformed the global energy market but is only developing slowly in Europe.Cuadrilla released a 12-second clip showing a bright yellow flame light up inside one of the chimney-like structures that stand over a web of pipes drilled deep into the ground.The gas flare was Cuadrilla’s evidence that fracking at the site was possible. The company said the question now was whether the entire process was commercially viable.”The volumes of gas returning to surface at this stage are small,” Cuadrilla chief executive Francis Egan said in a statement.”However it provides early encouragement that the Bowland Shale can provide a significant source of natural gas to heat Lancashire and UK homes and offices and reduce our ever growing reliance on expensive foreign imports.”Cuadrilla produced small amounts of shale gas at the same site in 2011. It was then forced to halt operations because two small earthquakes were soon registered in the northwestern part of England where its operations are based.It resumed work on October 15 after adopting more stringent safety and regulatory measures that environmentalists said were still insufficient.The company has since been forced to briefly halt drilling on three occasions because minor tremors began being detected deep underground.Cuadrilla stressed at the time that none of them could either be felt or cause physical damage on the surface.”This Preston New Road site is being monitored to an unprecedented level,” Egan said in Friday’s statement.”If we are able to fully test these wells, without compromising on safety, we have the potential to make a major difference to UK energy supply, security and economic prosperity.”The company said on its website that its tests from 2011 suggest that it can produce 6.5 billion cubic feet (185 million cubic metres) of gas from the Bowland Shale well over 30 years.last_img read more

Wheres the bus UW students new web tool tracks transit through the

first_img Explore further ©2019 The Seattle Times Distributed by Tribune Content Agency, LLC. University of Washington junior Kona Farry has, so he built a website, that lets transit users to track the whereabouts of all the buses, ferries, streetcars and light-rail trains in service in the Seattle region.The goal is to provide more real-time transit information to riders.His website, called the Puget Sound Transit Operations Tracker—or P-Track for short—uses GPS and other data publicly available from local and regional transit agencies to plot the positions of buses, trains and ferries along their routes.His page automatically updates every 30 seconds so users have up-to-date information.”It was born out of a desire to be able to see all the buses all at once and know what’s going on with the system,” said Farry, 21, who studies community, environment and planning at UW.For hard-core transit enthusiasts, information about each vehicle’s make and model, unique identification number, and even the size of the vehicle is available in the website.The site is free, and Farry does not make money off it. But users can support his work by making a one-time contribution or paying for a monthly subscription that supports ongoing development and server costs.P-Track differs from other transit trackers like King County Metro’s OneBusAway in that riders can see how individual buses are moving along a route as opposed to getting an estimate of when the bus will arrive. It also says whether a bus or train is running behind or ahead of schedule.For example, if you’re waiting for a bus on Third Avenue downtown, you can use OneBusAway or the Transit App to see that your bus is scheduled to arrive in 4 minutes. Then, you can open up P-Track, input the route you are tracking and see that your bus is still making its way through Pioneer Square.That can provide riders with additional information: Your bus is on its way, but it might take 5 or 6 minutes to get to your stop, not 4 as the other apps might say.”If a bus misses a light cycle or hits traffic, suddenly that estimate is off by several minutes,” Farry said. “You don’t watch that number slowly tick upward. You get a much better feel when you can say, ‘Oh the bus is right there, but it’s not moving. That’s why it’s not here yet.’ ” Credit: CC0 Public Domain Math explains why your bus route seems so unreliable On his site, Farry considers a bus on-time if it arrives between 2 minutes early and 5 minutes late. That’s the same as Metro’s definition.The website also can tell you how often buses on a particular route are late, very late, on time or early. Late buses are those that arrive between 5 and 15 minutes after they are expected. Very late buses come more than 15 minutes later than scheduled, and early buses come more than 2 minutes sooner than scheduled.Farry started working on the idea in December and, with limited coding experience, developed the website in less than four months, he said. He tapped Google, people on various internet forums and his roommate, a computer-science major, to help build the system.”I pretty much had to learn everything as I went,” he said.Farry said he became a self-described “transit geek” in the fall of 2016 when he moved from Marysville to Seattle for school and got to thinking about how to make transit work better.”That opened up this whole new world of riding the bus and going places for me,” he said. “I thought it was fascinating how there were so many buses out there going all over the city.”He regularly takes Metro’s Route 45, which runs between Loyal Heights and the University of Washington light-rail station. Farry also rides the Sound Transit Express Route 512 to Everett, where he then switches buses to get home to Marysville. And he sometimes rides Community Transit commuter buses between Snohomish and King counties.Over the summer, he plans to develop the website into an app for Apple phones. Android users could continue to view the platform on their mobile browser.In future versions, he’d like to add a traffic overlay so riders can see traffic conditions that could delay their trip.Farry would also like to collect timeliness information over time so passengers can see which routes tend to be early or late. Citation: Where’s the bus? UW student’s new web tool tracks transit through the Seattle region (2019, April 10) retrieved 17 July 2019 from https://phys.org/news/2019-04-bus-uw-student-web-tool.html Have you ever run to a bus stop just in time for its scheduled arrival only to end up waiting for the bus to show up? This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more