Sep 20, 2006 (CIDRAP News) – Roche announced last week that its United States supply chain for oseltamivir (Tamiflu), used to treat avian influenza and seasonal flu patients, is fully operational, meaning all aspects of its production are based on US soil.The company said it now has the capability to produce 80 million treatment courses of the drug annually in the United States, which is stockpiling oseltamivir as part of efforts to prepare for a flu pandemic.The US Department of Health and Human Services (HHS) had asked Roche to establish a system that involves US sources for all phases of osteltamivir production, from synthesizing shikimic acid, the starting material, to packaging the medication, the company said in a news release.”The ability to produce Tamiflu from start to finish on US soil is a significant milestone that will help ensure access to Tamiflu when and where it is needed,” said George Abercrombie, president and chief executive officer for Hoffman-La Roche, Inc., the company’s US pharmaceutical division.The company said HHS has ordered 21.3 million treatment courses of oseltamivir for the Strategic National Stockpile, all of which will be delivered by the end of this year. Marc Wolfson, a spokesman for the HHS Office of Public Health Emergency Preparedness in Washington, DC, verified that information for CIDRAP News.The long-term goal for the stockpile is 81 million courses by the end of 2008, according to Wolfson and Roche. Of that total, HHS says it will buy 50 million courses and will provide a 25% subsidy for states to purchase another 31 million courses.Roche says that with its own manufacturing network and 16 external contractors, it has more than enough capacity to meet the osteltamivir orders from 75 countries that are stockpiling the drug. Global annual production capacity will reach 400 million treatment courses by the end of this year, the company said.Approved for prevention and treatment of influenza in adults and children 1 year and older, osteltamivir is intended to treat influenza viruses in all clinical settings. It has been shown to be active against the H5N1 virus in the laboratory and in animals that are infected with an H5N1 avian flu strain taken from humans, according to Roche.See also:Sep 14 Roche press releasehttp://www.roche.com/med-cor-2006-09-14
Leornardia said that his office was in“constant communication” with the Palace since Duterte earlier agreed to gracethe festivity. BACOLOD City – President RodrigoDuterte will be here for one of the highlights of the 40th edition of theMassKara Festival, mayor Evelio Leonardia said. According to Leornardia, the Presidentis tentatively scheduled to come in Bacolod on Oct. 25. Leornardia added that the city’spolice force has rolled out its contingency plan in place in a bid to maintainthe peace and order situation during the festival highlights. It will be the President’s fourth timeto visit Bacolod. He was here last year when he opened the festival, which isconsidered as one of must see events in the country. He appealed to the public to cooperate as tighter security measures will be enforced during the final week of the festivities./PN
It was second against fourth before kick-off but, perhaps more intriguingly, Riyad Mahrez and David Silva were also locked in a playmaking play-off at the King Power Stadium. Everything Mahrez has touched this season has seemingly turned to goals for Leicester but how did the Algerian wizard compare to the man Manchester City fans call ‘Merlin’? Here, Press Association Sport assesses how two of the hottest Barclays Premier League properties compared in the top-of-the-table clash. Press Association GOAL THREAT Only Jamie Vardy and Romelu Lukaku had a better goals-per-game ratio than Mahrez heading into the game and the Algeria international came close to narrowing that gap midway through the first half. Mahrez, who has 13 Premier League goals this season, easily dispossessed Aleksandar Kolarov and fired a rasping 25-yard drive narrowly over Joe Hart’s bar. By contrast Silva, with just one league goal this term, rarely looked like adding to his modest tally and failed to muster a single effort on target before he was replaced in the 74th minute. CREATIVITY Arsenal’s Mesut Ozil may be streets ahead of anyone else in the Premier League assists chart but these two are arguably the German’s biggest threats. Ozil took his tally to 16 for the season against Bournemouth on Monday and while neither of Mahrez or Silva added to their total of seven, it was not for the want of trying. Silva, as he does so often, was roaming in the channels to good effect and Mahrez fed Marc Albrighton with a neat pass in the second half but he failed to finish from a narrow angle. INFLUENCE In a recent interview, Silva suggested that Mahrez was one of this season’s star performers so it is little wonder he has become a target for opposition defences. Stopping him is a different matter and Manchester City managed it well – aside from when Nicolas Otamendi took matters into his own hands towards the end of the first half with a robust challenge. Silva settled down to the task with some early interplay with the likes of Yaya Toure, Raheem Sterling and Sergio Aguero as the visitors set up camp in Leicester territory, but he faded away as the game wore on. DELIVERY Mahrez has been the master of the well-placed cross this term but he rarely had the chance on this occasion. Silva’s first corner was easily dealt with by Leicester while his second led to a Sterling shot that was easily saved by Kasper Schmeichel. The Spaniard was consistent in avoiding the first man – and an embarrassing replica of Kevin De Bruyne’s attempt at a corner at Arsenal which saw the Belgium kick the flag – but he failed to find the head of a team-mate from any of his attempts. SKILL Mahrez bagged an early nutmeg on £55million man De Bruyne and looked dangerous when he got between Manchester City’s midfield and defence – jinking past Fernandinho on a couple of occasions. He also left De Bruyne for dead in the last act of an entertaining goalless draw. Silva kept the flash touches to his counterpart but did embark on a seemingly impossible mazy run through the heart of Leicester’s defence on the hour mark which almost led to a Fernandinho goal. OVERALL CONTRIBUTION Mahrez had arguably his quietest day at the office this season and found space hard to come by. He did try to force his way into the game by switching flanks with Albrighton yet his best spells came from the centre of the pitch. The former Le Havre winger often found himself tracking back to counter the threat of Kolarov on Manchester City’s left but, as so often from this Leicester side, his work-rate was never in question. Silva, on the other hand, dictated much of Manchester City’s play in the opening 45 minutes with the movement of Sterling, De Bruyne and Aguero creating the space the Spaniard needs. Fitness has been an issue for the 29-year-old of late and that showed as the match entered its latter stages and he was replaced by Jesus Navas.
February 21, 2020 Northwestern looks to end streak vs Minnesota Share This StoryFacebookTwitteremailPrintLinkedinRedditMinnesota (12-13, 6-9) vs. Northwestern (6-19, 1-14)Welsh-Ryan Arena, Evanston, Illinois; Sunday, 3 p.m. ESTBOTTOM LINE: Minnesota looks to extend Northwestern’s conference losing streak to 11 games. Northwestern’s last Big Ten win came against the Nebraska Cornhuskers 62-57 on Jan. 11. Minnesota came up short in a 68-56 game at home to Indiana on Wednesday. SQUAD LEADERS: The versatile Daniel Oturu is averaging 19.6 points, 11.4 rebounds and 2.7 blocks to lead the charge for the Golden Gophers. Marcus Carr is also a key facilitator, accounting for 15.3 points, 5.8 rebounds and 6.7 assists per game. The Wildcats have been led by Miller Kopp, who is averaging 13.2 points.FACILITATING THE OFFENSE: Carr has either made or assisted on 44 percent of all Minnesota field goals over the last five games. The junior guard has accounted for 21 field goals and 30 assists in those games.WINLESS WHEN: The Golden Gophers are 0-6 when they allow at least 72 points and 12-7 when they hold opponents to anything below 72. The Wildcats are 0-17 when allowing 66 or more points and 6-2 on the season, otherwise.STREAK STATS: Northwestern has lost its last five home games, scoring an average of 59.8 points while giving up 72.6.DID YOU KNOW: The Northwestern offense has recorded a turnover on only 16 percent of its possessions, which is the 19th-best rate in the country. The Minnesota defense has forced opposing teams to turn the ball over on just 17 percent of all possessions (ranked 316th among Division I teams). ___For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP_Top25___This was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com Associated Press