Sep 20, 2006 (CIDRAP News) – Roche announced last week that its United States supply chain for oseltamivir (Tamiflu), used to treat avian influenza and seasonal flu patients, is fully operational, meaning all aspects of its production are based on US soil.The company said it now has the capability to produce 80 million treatment courses of the drug annually in the United States, which is stockpiling oseltamivir as part of efforts to prepare for a flu pandemic.The US Department of Health and Human Services (HHS) had asked Roche to establish a system that involves US sources for all phases of osteltamivir production, from synthesizing shikimic acid, the starting material, to packaging the medication, the company said in a news release.”The ability to produce Tamiflu from start to finish on US soil is a significant milestone that will help ensure access to Tamiflu when and where it is needed,” said George Abercrombie, president and chief executive officer for Hoffman-La Roche, Inc., the company’s US pharmaceutical division.The company said HHS has ordered 21.3 million treatment courses of oseltamivir for the Strategic National Stockpile, all of which will be delivered by the end of this year. Marc Wolfson, a spokesman for the HHS Office of Public Health Emergency Preparedness in Washington, DC, verified that information for CIDRAP News.The long-term goal for the stockpile is 81 million courses by the end of 2008, according to Wolfson and Roche. Of that total, HHS says it will buy 50 million courses and will provide a 25% subsidy for states to purchase another 31 million courses.Roche says that with its own manufacturing network and 16 external contractors, it has more than enough capacity to meet the osteltamivir orders from 75 countries that are stockpiling the drug. Global annual production capacity will reach 400 million treatment courses by the end of this year, the company said.Approved for prevention and treatment of influenza in adults and children 1 year and older, osteltamivir is intended to treat influenza viruses in all clinical settings. It has been shown to be active against the H5N1 virus in the laboratory and in animals that are infected with an H5N1 avian flu strain taken from humans, according to Roche.See also:Sep 14 Roche press releasehttp://www.roche.com/med-cor-2006-09-14
They had “drank bootleg alcohol over rumors that it would be effective in treating coronavirus and were poisoned”, it added.The poisoning toll in Khuzestan is higher than its 18 direct deaths from coronavirus, according to IRNA.Seven more people have died from bootleg alcohol in the northern region of Alborz and one in Kermanshah, western Iran.Alcohol is banned in Iran for everyone except some non-Muslim minorities, but local media regularly report on lethal cases of poisoning from bootleg liquor.Iran has scrambled to try to contain the spread of COVID-19 which has hit all of its 31 provinces, killing 291 people and infecting more than 8,000. Topics : The death toll from alcohol poisoning in Iran rose to 44 Tuesday, state news agency IRNA reported, over misguided efforts to ward off the new coronavirus by drinking bootleg alcohol.The outbreak of the virus in the Islamic republic is one of the deadliest outside of China, where the disease originated.The highest poisoning toll struck in the southwestern province of Khuzestan, where it grew by 16 to reach 36 on Tuesday, the agency said.
“The Fed continues to expect a December hike, as signalled by its dots chart,” he said.“However, there were otherwise doveish elements to (the) announcement, including a lowering of short-run growth and inflation forecasts and long-term growth, unemployment and the Fed funds rate projections.”He said AXA IM believed the FOMC was likely to hike in December, particularly if the Q3 employment cost index shows some signs of revival.“In the interim, we expect speculation to rise that the Fed will not tighten policy this year,” he said.In a global research report, Bank of America Merrill Lynch said the Fed’s decision was about as doveish as it could be for equity investors, with the committee members having committed to watch international developments.“Similar to deferral of Fed tapering in 2013, we see this as supportive to equities given the de-risking already undertaken,” it said.Peter O’Flanagan, head of foreign exchange trading at ClearTreasury, also noted the way the Fed statement referred to worries about the slowdown in the external environment.“Previously, the Fed had indicated it would be focused on the domestic economy when making decisions around rate hikes, but things have certainly changed,” he said.“Now, it is looking at events in China and other emerging markets and their potential impact on global growth.”Although the Fed maintained it still expected to hike this year, O’Flanagan said December was the only real possibility for this to happen.He said he saw the first quarter of next year as a more realistic target.Lee Ferridge, head of North American macro strategy at State Street Global Markets, said the Fed’s international focus had increased the importance of dollar strength, with the US currency being “the doorway by which the global economy affects the domestic one.”“Now it’s a waiting game again, and every upcoming meeting is on the table so long as data and conditions can justify a move,” he said.“However, there is no guarantee the conditions will be satisfactory ahead of the end of 2015.”Meanwhile, Rick Rieder, CIO of fundamental fixed income at BlackRock, said there were strong signals that a rate hike before the end of the year was very probable.Rieder said the timing of the next increase was much less important than the pace of credit tightening, and that the Fed had already said it would be measured in its approach.“It is very clear the Fed’s monetary policy this upcoming cycle will be nothing like the historic tightening cycles of the past in terms of the consistency of movement at each meeting, or the long-term trajectory of significant rate rises,” he said.Felix Wintle, head of US equities at Neptune Investment Management, also said he expected a rate cut this year.“At Neptune, we are still confident the Fed will raise rates in 2015 and believe December is now the most likely time for this,” he said.Even though the language accompanying yesterday’s decision was doveish, rate rises may come quicker than the market expects, he said.Rising rates will change the investment landscape, he said, with a rising rate environment creating winners and losers among sectors and stocks.“This is because, as interest rates rise, so does the cost of capital – i.e. the cost of credit to corporates,” he said.He said this spelled trouble for companies relying on raising capital to run their business and those that were highly geared.At Amundi, Philippe Ithurbide, global head of research, strategy and analysis, and Bastien Drut, head of strategy and economic research, saw December as the most likely time for the FOMC to make its first rate hike.“But it will stay in very gradual mode and, at the most, tighten by 25 basis points per quarter,” they said.Robeco’s chief economist Léon Cornelissen said that, if the economic climate remained favourable, the most likely scenario was for the Fed to make a first modest rate hike in December, followed by an explanatory press conference by Yellen. The US Federal Reserve’s decision yesterday to hold its key interest rate at zero, coupled with its cautious comments and new focus on the possible impact of external factors, means the cost of central bank credit may stay put until next year, according to asset managers and economists.Although most expected a rate rise to happen in December, many analysts also scrutinised comments by Fed chair Janet Yellen following the decision, which were seen as indicating a more doveish attitude to raising interest rates, as well as a downward revision in its long-term rate outlook.At its meeting yesterday, the Federal Open Market Committee (FOMC) left the Fed funds rate unchanged at 0.00-0.25%.At AXA Investment Managers (AXA IM), senior economist David Page said it was important the Fed lowered its long-term rate outlook to 1.8-2.2% from 2-2.3%.
Reno passion project pays off The rooftop terrace has sublime ocean views. Features such as thick windowsills and doorways, an earthy colour scheme and seamless indoor and outdoor living gives a sense of comfort. The remodelled kitchen features two dishwashers, granite benchtops, ample storage and a large island. Even the interior styling, which is being sold with the property, will have you dreaming of a Mediterranean escape.“They did a major renovation of the kitchen and living areas, they put in solar and they extended the terrace at the front,” Mr Conolly said. Every element has a European feel, from the ornate doorways to the handmade banister, the soaring tower with your very own observation room and a rooftop terrace. Luxury Noosa home fetches $8 million Four bedrooms are housed downstairs, including the master suite with views over the sparkling pool and spa as well as out to a sunny, private courtyard. MAMMA MIA: ‘Mykonos’ on Duke St, Sunshine Beach (Noosa) will have you thinking you’ve arrived on the Cyclades island for the Grecian summer. The home can accommodate up to 16 people with the library and tower observation room (pictured) offering extra sleeping space. RELATED: Inspired by the whitewashed houses lining the hills of Mykonos, Greece, this Noosa home will have you thinking you’ve transported to the Cyclades island for the Grecian summer. Ricciardo living in lap of luxury Every element has a European influence. More from newsParks and wildlife the new lust-haves post coronavirus13 hours agoNoosa’s best beachfront penthouse is about to hit the market13 hours agoThe kitchen and living spaces have undergone an extensive renovation since the owner purchased the property in 2011.“Obviously the painting and the general maintenance has been excellent and they did a full renovation of all the bathrooms and then they’ve furnished it, so it’s suitable, or perfect for a holiday rental.“Overall it’s in great condition and the presentation is awesome.” MORE: Designed almost 30 years ago by a couple of artists and almost completely overhauled by the current owner, selling agent Century 21 Conolly Hay Group co-principal David Conolly said Mykonos House is known to Sunshine Beach locals as “The Palace”. >>FOLLOW EMILY BLACK ON FACEBOOK<< And it’s no wonder why, as it was one of the first million-dollar builds in Sunshine Beach and has private parking for up to six cars and when used as a holiday home, it can accommodate up to 16 people with the library and tower observation room offering extra sleeping space. There is even an inground pool.